Ligand dex

Dicționar dexonline. Definiții, conjugări, declinări, paradigme pentru ligand din dicționarele: D Ligand Definition and Summary of DEX. DEX is a Ligand Of Interest in 4UDC designated by the RCSB. Help . Best-fitted instance in this entry: Other instances in this entry: Best-fitted instance in this entry : Best-fitted PDB instances with the same target (top 5

A noncanonical Wnt ligand (Wnt5a) was upregulated by DEX as demonstrated by Wnt ligand degenerate PCR, real-time quantitative PCR (qRT-PCR), and Western blotting. Knocking-down Ror2, the receptor of noncanonical Wnt signaling, abolished the effects of DEX on the TM cells In the absence of the steroid-ligand dexamethasone (DEX), the chimeric protein remains in the cytoplasm where it is sequestered by HSP90 protein complex, and cannot enter the nucleus (Picard, 1993). Upon addition of DEX, the chimeric protein is freed from its interaction with HSP90 and can localize to the nucleus and exert its function Mammalian steroid receptor ligand-binding domain (LBD) fusions have been used in a range of organisms and cell types to inactivate proteins of interest until the cognate steroid ligand is applied

Finally, cry1-/-;cry2-/- mice subjected to 8 weeks of chronic Dex treatment exhibited incomplete suppression of circulating corticosterone and greater glucose intolerance compared with wildtype littermates subjected to the same chronic treatment, consistent with enhanced transcriptional response to the synthetic glucocorticoid ligand To determine the status of GR in the cytoplasm and nucleus in the presence or absence of the GR ligand DEX, co-IP, confocal microscopy, and reporter assays were performed. Dysfunction of GR by mutation of P625, which is not located in the ligand-binding pocket or the well-known DNA-binding dimer interface H10 or H11 [ 32 ], is reported We have now used the chromatin immunoprecipitation assay (ChIP) to assess promoter occupancy of these proteins, in vivo, in the presence and absence of the ligand, Dex. Dex causes a remarkable increase in the binding of glucocorticoid receptor, polymerase II, CBP and p300 to the promoter

(Redirected from Isopto-Dex) Dexamethasone is a type of corticosteroid medication. It is used in the treatment of many conditions, including rheumatic problems, a number of skin diseases, severe allergies, asthma, chronic obstructive lung disease, croup, brain swelling, eye pain following eye surgery, and along with antibiotics in tuberculosis SAN DIEGO-- Ligand Pharmaceuticals Incorporated (NASDAQ: LGND) today announced it has acquired privately held CyDex Pharmaceuticals, Inc. for a combination of cash and contingent payments. CyDex, based in Lenexa, Kansas, had 2010 revenue of $16.3 million and EBITDA of $7.6 million, and will operate as a wholly-owned subsidiary of Ligand

(a) In contrast to the effects of the MR agonist ALDO (10 −5 M), the GR ligand DEX (10 −5 M) induces significant levels of apoptosis in hippocampal cultures. The apoptotic potential of DEX is. We present evidence to support that the combination of CpdA with Dexamethasone (DEX), a classic steroidal GR ligand, can shape GR function towards a unique gene regulatory profile in a cell.. DEX binds more tightly to AncGR2 LBD and has higher potency in transactivating GREs than HCY. (A and B) Chemical structures of GR endogenous ligand cortisol/HCY (A) and synthetic ligand DEX (B). Structures show canonical steroid carbon and oxygen atom (in gray circle) numbering

ligand - definiție DE și paradigmă dexonlin

Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES; DEX : A:247; B:247; Valid; Valid; none; none; submit dat DEX (1‑10 µM) was added to the cell culture media and incubated for 24‑72 h. The results revealed that DEX upregulated the mRNA and protein levels of P‑gp in a dose‑ and time‑dependent manner. Subsequently, tumor necrosis factor‑related apoptosis‑inducing ligand (TRAIL) was used for the induction of apoptosis in the cells. Ligand's 2011 operating expenses are expected to be $16 million to $18 million, with an average cost of goods as a percentage of material sales to be approximately 35%. If Ligand borrows an. AGREEMENT AND PLAN OF MERGER . This AGREEMENT AND PLAN OF MERGER (this Agreement), dated August 10, 2020, is by and among Ligand Pharmaceuticals Incorporated, a Delaware corporation (Parent), Pelican Acquisition Sub, Inc., a Delaware corporation and a wholly-owned subsidiary of Parent (Acquisition Sub), and Pfenex Inc., a Delaware corporation (the Company) Administration of exogenous GC, such as hydrocortisone and dexamethasone (DEX), are widely used to suppress inflammation, although the mechanisms through which they act are not entirely clear . Administration of exogenous GCs as antiinflammatory agents provides systemic ligand to all cells expressing the glucocorticoid receptor (GR)

Ligand validation:4UD

1. J Exp Med. 1994 Feb 1;179(2):739-43. The type II receptor as a decoy target for interleukin 1 in polymorphonuclear leukocytes: characterization of induction by dexamethasone and ligand binding properties of the released decoy receptor Within the TNF superfamily, OX40L, glucocorticoid-induced TNF receptor ligand (GITRL), and 4-1BB ligand (4-1BBL) have costimulatory function for T cells . To investigate whether OX40L is unique in the inhibition of IL-10-producing Tr1 cells, naïve CD4 + T cells were cultured with anti-CD3 plus anti-CD28 mAbs with Dex + Vit D3, with parental L.

GR tethering occurs at different ligand concentrations and

Name : Jurisdiction of Incorporation: Glycomed Incorporated : California: Allergan Ligand Retinoid Therapeutics, Inc. Delaware: Ligand Pharmaceuticals International, Inc CRHR1 and CXCL5 signaling in the hippocampus are involved in spatial learning and memory deficits caused by prenatal DEX exposure. CRHR1 activation contributes to decreased CXCL5 production in hippocampus induced by prenatal DEX treatment. Our study provides a molecular basis of prenatal GC exposure programming spatial learning and memory

Dexamethasone induces cross-linked actin networks in

A dexamethasone-inducible gene expression system is active

Within the ligand-binding pocket, the same side chains participate in hydrogen-bonding interactions, including a water molecule in all structures . This is not surprising when comparing Dex and TA, as the ligands are almost identical except for the acetonide moiety, which is contacted by hydrophobic interactions (Dex), are widely prescribed anti-inflammatory drugs that acti-vate the nuclear receptor glucocorticoid receptor (GR) (Oakley and Cidlowski, 2013). Ligand-bound GR translocates to the nu-cleus to control target gene expression through GC response elements (GREs) or other binding sites present in promoters or enhancers Dexamethasone is a synthetic glucocorticoid compound with potent anti-inflammatory activities. It represses a large set of pro-inflammatory genes by blocking NF-κB and MAPK activation during TLR engagement depending on the TLR ligand and whether the adapters MyD88 and TRIF are activated individually or coincidently [1]

A New Tool for Inducible Gene Expression in Caenorhabditis

  1. In a ligand screen for orphan G-protein coupled receptors DEX treatment improves neurological symptoms; after resection, DEX may reduce options for targeted therapy (e.g., immunotherapy) in phase 2. In phase 3, during chemotherapy and tumor recurrence, DEX shows no change. For Apelin-F13A (F13A) therapy, there is evidence that it could.
  2. α-DEX ™ 120 was used in a GC column, in an experiment conducted to study the addition of catalytic enantioselective diethylzinc to a-substituted aldehyde, in presence of enantiopure ligand. It was also used to pack chiral column durin GC analysis, in an experiment to investigate lipase-mediated desymmetrization of glycerol with aliphatic and aromatic anhydrides
  3. Dexamethasone is a type of corticosteroid medication. It is used in the treatment of many conditions, including rheumatic problems, a number of skin diseases, severe allergies, asthma, chronic obstructive lung disease, croup, brain swelling, eye pain following eye surgery, and along with antibiotics in tuberculosis. In adrenocortical insufficiency, it should be used together with a medication.
  4. In vitro GR ligand binding assay and Dex and HSP90 competition assays We grew U2OS cells stably expressing GR to 100% confluence and then isolated cytosolic fractions as previously described ( 47 ). Cytosol (5 to 10%) supplemented with 20 mM sodium molybdate was added to varying concentrations of [ 3 H]Dex (0 to 25 nM) ± 100-fold excess of.
  5. Approximately, ~ 40% of DEX released in first 12 h compared to that of ~ 30% for siRNA during the same time period at 37 °C. Similarly, ~ 60% of DEX was released towards the end of 24 h compared to ~ 40% for the siRNA. On contrast, relatively lower drug release was observed at 4 °C for both the therapeutic components
Three putative binding sites in the ligand binding domain

DEX (1-10 µM) was added to the cell culture media and incubated for 24 -72 h. The results revealed that DEX upregulated the mRNA and protein levels of P-gp in a dose- and time-dependent manner. Subsequently, tumor necrosis factor -related apoptosis- inducing ligand (TRAIL) was used for the induction of apoptosis in th CCL2 Chemokine (C-C motif) ligand 2 Dex Dextran DBTDL Dibutyltin dilaurate DMSO Dimethyl sulfoxide W d Dry weight of the hydrogel EGF Epidermal growth factor ECM Extracellular matrix H&E Hematoxylin & eosin HBEGF Heparin-binding epidermal growth factor ITGAV Integrin subunit α-v ITGB3 Integrin subunit β-3. Twenty-seven children with congenital heart disease were studied, median (IQ) age 7 (0.4-10) months. Patients were given 0.25 mg/kg dexamethasone (DEX) (n = 13) or no DEX (n = 14) at induction of anaesthesia.Groups were well matched in terms of age, type of operation, length of CPB, cross clamp, and circulatory arrest (all P > 0.15). sFas, sFasL and interleukin (IL) 6 (a marker of cytokine. to K562 was strongly inhibited by diSia-Dex, but not by Dex alone, indicating that Siglec-7 binding was competitive with diSia epitopes. To determine the ability of diSia-Dex to release the counter-receptor from Siglec-7, we performed a pull-down assay for K562 cell homogenates and attempted to elute the ligand using diSia-Dex

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  1. The C-17α furoate group allows MF to fully occupy the GR ligand-binding pocket. (A, B) Three-dimensional structures of DEX (green) and MF (magenta)
  2. 3H-DEX and 3H-ALDO by the different hippocampal subfields. Inspection of the autoradiograms gener-ated from the dorsal hippocampus revealed intense labeling of the dentate gyrus and CA1 areas with 3H-DEX, whereas the CA1-CA3 areas were less intensely labeled with this specific GR ligand; lesser labeling was noticed in the CA2-CA3 areas (Fig.
  3. Glucocorticoid receptor in green, with ligand-binding domain (top; PDB: 1m2z) and DNA-binding domain (bottom; PDB: 1glu ), co-activators in salmon, and DNA in purple. The flexible linker of the protein is not included in the structures and is represented schematically with dots. Dexamethasone, shown in a magnified view, is hidden within the.
  4. Ligand stimulation with either cortisone or dexamethsone (DEX) acutely elicited GR translocation to the nucleus and, comparably, ligand-independent stimulation either with the Th2 cytokine, IL-13, or the pleiotropic cytokine combination, IL-1b/TNFa, also acutely evoked GR translocation
  5. 2039 Dex-regulated genes, while Dex was still able to . regulate 1087 genes in GRKD cells. Of these 1087 genes, The glucocorticoid receptor (GR) is a ligand-regulated transcription factor (TF.
  6. A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related field
  7. Importantly, ligand-dependent GR activation (i.e., in Dex-treated cells) remained similar across these models as measured by qPCR analysis of two well-characterized GR target gene (DUSP1 and SGK1) mRNAs, indicating that ligand-bound S134A-GR is not transcriptionally impaired (Fig. 5d). Further studies are needed to evaluate the role of Ser134.
(PDF) Structures and mechanism for the design of highly

Glucocorticoid receptor dimerization in the cytoplasm

Ligand gains a range of therapies for bipolar disease, schizophrenia and canine motion sickness. Ligand will now combine the royalties from seven marketed drugs, along with the substantial. activates PXR. In addition, submicromolar concentrations of DEX also enhance the expression of the constitutive androstane receptor (CAR) and the retinoid X receptor-alpha in human hepatocytes (Pascussi et al., 2000a; Pascussi et al., 2000b). It has been demonstrated that DEX is a more potent ligand for mouse PXR than the huma CyDex Pharmaceuticals, Inc. is a specialty pharmaceutical company developing products and licensing its Captisol technology. Captisol is currently incorporated in five FDA-approved medications and marketed by three of the company's licensees: Pfizer, Bristol-Myers Squibb and Prism Pharmaceuticals

Hormonal regulation of assembly of the pepck gene

Dexamethasone - Wikipedi

Doubling the Size of the Glucocorticoid Receptor Ligand

In this content, a small molecular ligand of prostate specific membrane antigen (SMLP) conjugated poly (caprolactone) (PCL)-b-poly (ethylene glycol) (PEG) copolymers with different block lengths were synthesized to construct a satisfactory drug delivery system. Four different docetaxel-loaded polymeric micelles (DTX-PMs) were prepared by dialysis with particle sizes less than 60 nm as. The Scientific Statement of the Endocrine Society postulates that EDCs have effects on female and male reproduction, metabolism, obesity, neuronal function, endocrine and cardiovascular systems, and several cancer types ( Diamanti-Kandarakis et al., 2009 ). Diverse pathways contribute to the ubiquitous presence of EDCs in aquatic ecosystems Stimulation of Dex-DC with beta-glucans induced a strong upregulation of Syk phosphorylation and increased secretion of IL-10, while the production of IL-12, IL-23 and TNF-alpha was reduced Cellufine MAX DexS is a new chromatography resin incorporating Dextran sulfate polymer surface modification. This non-animal derived pseudo affinity ligand can be used instead of immobilized Heparin for blood protein fractionation and viral capture. DexS-HbP developed for purification of heparin binding proteins. DexS-VirS, for purifying virus and virus like particles especially having.

The results of Table 2 show the degree of substitution of folate ligand per each mole of DEX. This table shows that there is no quantitative correlation between the surface conjugated folate ligand with the feeding ratio of folic acid, and when 7 moles (in DEX 10000) or 4.2 moles (in DEX 6000) are applied almost a constant amount of this. dexamethasone {DEX), a strong synthetic glucocorticoid. Induction levels of the luciferase activity were well correl- ated with DEX concentrations in the range from 0.1 to 10 liM and the maximum expression level was over 100 ligand to a HBD results in de-repression (Picard, 1993). W

Ligand Acquires CyDex Pharmaceuticals :: Ligand

This is likely due to the fact that dex ac-celerates both ligand-dependent and ligand independent AHR protein degradation in a GR-dependent manner [25]. Pharmaceuticals 2021, 14, 211 4 of 16 Figure 3. Modulation of IDO1 and TDO2 by interferon gamma (IFN-) or dex DEX +20 III DEX +30 IV DEX +35 V DEX +40 Toughness I MEL Def +10 Alter / Flict / Ligand. Only one Augment from this category can exist on an item. Cannot coexist with Stigma. Name Effect Notes Alter Arma MEL Pwr +20 HP +30 Can be found on weapons in the Astracite Exchange Shop

Direct targeting of hippocampal neurons for apoptosis by

  1. Ligand Pharmaceuticals (LGND: Nasdaq) By Roth Capital Partners ($101.94, Sept. 21, 2015) We reiterate our Buy rating and $135 price target on Ligand Pharmaceuticals. We recommend steady.
  2. of ligand, such that the receptor must change its conformation to allow entry of the ligand (7). Hsp90 binds to the ligand binding domain (LBD) of the receptors (1), and the hsp90/ hsp70-based chaperone machinery carries out an ATP-depend-ent opening of the binding cleft in the GR LBD such that it can be accessed by steroid
  3. Programmed cell death 1 (PD-1) is a key cell-surface receptor of CD28 superfamily that triggers inhibitory pathways to attenuate T-cell responses and promote T-cell tolerance. As a crucial role in tumor immunity, PD-1 has been a focus of studies in anti-cancer therapy. It has been approved that tumors could exploit PD-1-dependent immune suppression for immune evasion

Glucocorticoids (GC) are among the most effective anti‐inflammatory drugs, but are often associated with serious adverse effects or inadequate therapeutic responses. Here, we use activation of differ.. DEX activates PPARγ (for which 15d-PGJ 2 acts as an endogenous ligand) in hearts, and the cardioprotective effect of DEX was cancelled in PPARγ antagonist-pretreated hearts, whereas DEX also failed to increase the expressions of L-PGDS-dependent Nrf2 target genes in these hearts. Finally, DEX increased the mRNA expression of Nrf2 in a. Chemical biology tools for probing transcytosis at the blood-brain barrier R. Beard, D. C. A. Gaboriau, A. D. Gee and E. W. Tate, Chem. Sci., 2019, 10, 10772 DOI: 10.1039/C9SC04024B This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that.

Dexamethasone protects normal human liver cells from

form of the decoy molecule induced by Dex from PMN were, respectively, 100 and 2 times higher compared with IL-1/3. The induction by Dex of the type II receptor, a decoy molecule for IL-1, may contribute to the immunosuppressive and antiinflammatory activities of Dex DEX loaded with the iNKT-cell ligand α-galactosylceramide (αGC) activates CD4+ T cells, OVA-specific CD8+ T and B lymphocytes, which then improves the survival rate and survival time in a B16 melanoma mouse model . Exosomes: effective markers for the adaptive immune activation of immunotherapy ligand for OPGyOCIF and identical to ODF. Thus, we screened a cDNA expression library of ST2 cells treated with 1,25(OH)2D3 and Dex to isolate the cDNA encoding the OPGyOCIF binding protein. Here we report that the protein is a member of the membrane-associated TNF ligand family and has characteristics that satisfy the major criteria of ODF Dex inhibited the expression of LPS-induced genes between 43 (chemokine (C-C motif) ligand 3 [CCL3]) and 98% (CSF2). Three distinct groups of genes could be recognized. COX-2, IFN-γ, IL-1α, and IL-1β were all strongly inhibited by Dex, and inhibition was severely impaired in DUSP1 −/− BMMs (Fig. 3, top) Two kinds of commercially available ligand-carrier conjugates that have the same group-specific ligand, Reactive Blue 2, were used in these experiments. One is Blue Dextran, which is a water-soluble conjugate composed of the ligand and water-soluble polymer dex- tran with a molecular weight of approximately 2 x 10

Dexamethasone (DEX)-induced osteopenia zebrafish larvae has been proved to be a well-established animal model for study of osteoporosis. 34 In this study, zebrafish larvae at 96 hpf (hours post fertilization) were exposed to DEX solutions with a concentration of 25 μM/L (DEX+), and 0.01% DMSO (DEX-) was selected as the vehicle control Receptor assays are performed with a final volume of 250 μL containing from 50-75 μg of extract protein, plus 1-2 nM [3H]Dex at 84 Ci/mmol and varying concentrations of competing ligand (0 to 10 μM). Assays are set up using a 96-well minitube system, and incubations are carried out at 4°C for 18 h dexamethasone (DEX)-induced osteoporotic mouse model the nuclear receptor superfamily of ligand-activated transcriptional factor. It mediates cellular effects of GCs and is widely expressed in almost all cells of the body [27, 28]. The GR consists of four major domains: th

Ligand stimulation with either cortisone or dexamethsone (DEX) acutely elicited GR translocation to the nucleus and, comparably, ligand-independent stimulation either with the Th2 cytokine, IL-13, or the pleiotropic cytokine combination, IL-1β/TNFα, also acutely evoked GR translocation Glucocorticoid Ligand Mixtures Bioassay 1. Abstract: Raw data for glucocorticoid receptor ligand exposure experiments. This dataset is associated with the following publication: MedlockKakaley, E., M. Cardon, E. Gray, P. Hartig, and V. Wilson. Generalized concentration addition model predicts glucocorticoid activity bioassay responses to. In aggregate, these data suggest that GR can interact with chromatin through noncanonical binding sites in the absence of supplemental ligand. Addition of dex abrogates detection of antibody-GR complexes at these sites, frequently in association with reduced RNAPII occupancy and transcription Particularly, tumor necrosis factor related apoptosis-inducing ligand (TRAIL) displays core role in regulating these processes and then contribute to pathological damage. Pathologically, the activation of proapoptotic and pro-necroptotic pathways, which can result in a structural disruption of the airway, is a major hallmark of pathological.

Glucocorticoid Receptor Function Regulated by Coordinated

Compound A influences gene regulation of the Dexamethasone

after transfection, Dex was added to +Dex wells to a final concentration of 100 nM and luciferase activity was measured 24h after ligand addition (2 days after transfection). Luciferase activities are shown as relative luciferase units (RLU) after normalization by b-gal activity. 6162 NucleicAcidsResearch,2007,Vol.35,No.1 Stimulation by 1 alpha,25 dihydroxyvitamin D3 [1,25(OH)2D3] plus dexamethasone (Dex) augmented RANKL and diminished OPG mRNA expression in fibroblastic cells and caused the formation of numerous osteoclasts in cocultures of skin fibroblastic cells with hemopoietic cells or monocytes tion with pomalidomide and dexamethasone (Dex) (Pd) in RRMM based on improved PFS in a phase III trial (PFS: Isa-Pd 11.3 m vs Pd 6.5 m).7 Isa combines well with immu-nomodulatory drugs, and this was also noted in a phase I study of Isa combined with Len and Dex (Rd). 8 Response rates in the Isa-Pd and Isa-Rd ranged between 60% an The GR, encoded by the NR3C1 gene, is a member of the nuclear receptor superfamily of ligand-activated transcriptional factor. It mediates cellular effects of GCs and is widely expressed in almost all cells of the body [27, 28].The GR consists of four major domains: the NH2-terminal transactivation domain (NTD) or activation function 1 (AF-1), DNA-binding domain (DBD), hinge region, and ligand. Vincent Antle SVP of Technical Operations and Quality Assurance Olathe, Kansas, United States 457 connection

A Structural Explanation of the Effects of Dissociated

We have demonstrated that dexamethasone (dex) potentiates the antitumor effect of calcitriol and decreases calcitriol-induced hypercalcemia. Both in vitro and in vivo, dex significantly increases vitamin D receptor (VDR) ligand binding in the tumor while decreasing binding in intestinal mucosa, the site of calcium absorption Su dex 18-electron rule 137 2c-2e bon 12 3c-2e bond α disintegration 58 acceptor number 157 51 acetylacetonato 12 acid 48 aconitase 163 actinoid 155 adenosine triph 75 agostic interaction 1 70 34 albite alkali metal 101 alkaline earth metal alkyl ligand 03 34 allosteric effect 64 allotrope 7 alnico magnet alumina 1 81 70 aluminosilicate 7 94 0.

Chemistry Group Directory

First High-Resolution Crystal Structures of the

A spectrochemical series is a list of ligands ordered on ligand strength and a list of metal ions based on oxidation number, group and its identity. In crystal field theory, ligands modify the difference in energy between the d orbitals (Δ) called the ligand-field splitting parameter for ligands or the crystal-field splitting parameter, which is mainly reflected in differences in color of. EP2524057B1 EP11733207.2A EP11733207A EP2524057B1 EP 2524057 B1 EP2524057 B1 EP 2524057B1 EP 11733207 A EP11733207 A EP 11733207A EP 2524057 B1 EP2524057 B1 EP 2524057B1 Authorit SPD and DEX were diluted in saline and abdominally injected daily from days 27 to 48. The normal control and CIA control groups were administered an equal volume of saline on the same schedule. On day 49, the mice were euthanized, and their ankle joints were harvested for histological and immunohistochemical analyses

Inhibition of adipocyte differentiation by mechanical

Dexamethasone promotes osteoclastogenesis by inhibiting

NKT cells activated in the presence of LEN have greater ability to secrete interferon-γ. Antigen-dependent activation of NKT cells was greater in the presence of dexamethasone (DEX) plus LEN than with DEX alone. Therapy with LEN/Thal also led to an increase in NKT cells in vivo in patients with myeloma and del5q myelodysplastic syndrome The expansion of antigen-specific CD8 T cells is important in generating an effective and long-lasting immune response to tumors and viruses. Glucocorticoid-induced tumor necrosis factor receptor family-related receptor (GITR) is a co-stimulatory receptor that binds the GITR ligand (GITRL). Agonism of GITR can produce important signals that drive expansion of effector T cell populations Ligand Pharmaceuticals, Inc. is a biopharmaceutical company, which engages in developing or acquiring technologies that help pharmaceutical companies discover and develop medicines. Its products include evomela, IV voriconazole, duavee, viviant/conbriza, nexterone, and noxafil-IV Moreover, the DEX membrane contains the activating receptor NKG2D ligand, which is responsible for the activation and proliferation of NK cells . Although DCs have been pulsed with TLRs, biomarkers, and tumor antigens derived from lysates, TDE-pulsed DCs were reported to generate the most remarkable results as a potential anti-tumor vaccination